Kaufman L D, Krupp L B
Department of Medicine, State University of New York at Stony Brook 11794-8161, USA.
Curr Opin Rheumatol. 1995 Nov;7(6):560-7. doi: 10.1097/00002281-199511000-00016.
The similarity of eosinophilia-myalgia syndrome (EMS) and toxic-oil syndrome (TOS) to systemic sclerosis and diffuse fasciitis with eosinophilia (DFE) highlights the potential for environmental agents to induce autoimmune disease. Further, a candidate etiologic agent for EMS, 3-(phenylamino)alanine, is chemically similar to the aniline derivative identified in samples of oil implicated in TOS, 3-(N-phenylamino)-1,2-propanediol, suggesting pathogenic overlap. The late-stage manifestations of EMS and TOS are muscle cramping, arthralgia, severe fatigue, and cognitive impairment. This review focuses on the divergent and parallel findings in EMS, TOS, and DFE. The formation of the Environmentally Associated Connective Tissue Disease Study Group within the American College of Rheumatology will provide a forum for the development of registries to study suspected toxin-induced disorders.
嗜酸性粒细胞增多性肌痛综合征（EMS）和中毒性油综合征（TOS）与系统性硬化症及嗜酸性粒细胞增多性弥漫性筋膜炎（DFE）的相似性凸显了环境因素诱发自身免疫性疾病的可能性。此外，EMS的一种候选致病因子3-（苯氨基）丙氨酸在化学结构上与在TOS相关油样中鉴定出的苯胺衍生物3-（N-苯氨基）-1,2-丙二醇相似，提示存在致病重叠。EMS和TOS的晚期表现为肌肉痉挛、关节痛、严重疲劳和认知障碍。本综述聚焦于EMS、TOS和DFE中不同及平行的研究结果。美国风湿病学会内环境相关性结缔组织病研究小组的组建将为建立登记系统以研究疑似毒素诱发疾病提供一个平台。
