Burt R A, Morgan T, Payne J P, Bonner R M
Br J Urol. 1977 Apr;49(2):147-52. doi: 10.1111/j.1464-410x.1977.tb04089.x.
Cinoxacin, a synthetic antibacterial compound, was given orally in a dose of 500 mg to 8 patients undergoing transurethral prostatectomy. The drug was well absorbed and the peak plasma level (mean 13.9 mcg/ml) occurred 1 or 2 hours after administration. Concentrations of cinoxacin in the urine reached a peak (mean 236.5 mcg/ml) 4 to 6 hours after dosing, and remained higher than the mean MIC for most common urinary pathogens for 12 hours after administration. The concentration of cinoxacin in prostatic tissue 2.5-4 hours after administration varied between 0.6 and 6.3 mcg/g. The individual variations were unrelated to the concurrent plasma level and appeared to be influenced more by inter-subject variation than by the physicochemical properties of the drug. In 1 patient the cinoxacin level was estimated in renal tissue (70.1 mcg/g), in muscle (12.6 mcg/g), and in perirenal fat (4.7 mcg/g).
西诺沙星是一种合成抗菌化合物，以500毫克的剂量口服给予8名接受经尿道前列腺切除术的患者。该药物吸收良好，给药后1至2小时达到血浆峰值水平（平均13.9微克/毫升）。给药后4至6小时，尿液中西诺沙星浓度达到峰值（平均236.5微克/毫升），给药后12小时内，其浓度一直高于大多数常见尿路病原体的平均最低抑菌浓度。给药后2.5至4小时，前列腺组织中西诺沙星浓度在0.6至6.3微克/克之间变化。个体差异与同时期的血浆水平无关，似乎更多地受到个体间差异的影响，而非药物的物理化学性质。在1名患者中，测定了肾组织（70.1微克/克）、肌肉（12.6微克/克）和肾周脂肪（4.7微克/克）中的西诺沙星水平。
