Israel K S, Black H R, Nelson R L, Brunson M K, Nash J F, Brier G L, Wolney J D
J Clin Pharmacol. 1978 Oct;18(10):491-9. doi: 10.1002/j.1552-4604.1978.tb01577.x.
Cinoxacin is a new synthetic organic antibacterial compound which has a serum half-life of approximately 1 hour. Most of the drug is eliminated in man by the kidney, primarily as unchanged drug. The renal clearance of cinoxacin is slightly greater than the usually accepted value for the average glomerular filtration rate, which suggests that it is probably filtered and is also secreted by the tubule. Results after pretreatment with probenecid further suggest secretion of the drug.
西诺沙星是一种新型合成有机抗菌化合物，其血清半衰期约为1小时。该药物在人体内大部分经肾脏排泄，主要以原形药物排出。西诺沙星的肾清除率略高于通常所接受的平均肾小球滤过率值，这表明它可能经滤过且也由肾小管分泌。丙磺舒预处理后的结果进一步提示该药物存在分泌现象。
