Döbrössy M D, Svendsen C N, Dunnett S B
MRC Cambridge Centre for Brain Repair, University of Cambridge, UK.
Neuroreport. 1995 Oct 23;6(15):2049-53. doi: 10.1097/00001756-199510010-00023.
It has been previously shown that lesions of the dorsal striatum can disrupt performance on a variety of cognitive tasks related to frontal cortex function. In order to extend these studies, we have investigated the effects of bilateral striatal lesions on the acquisition of an operant test of short term memory in the delayed non-matching to position paradigm. The animals received either ibotenic acid or saline control injections into the dorsal striatum prior to training on the non-matching task. Striatal lesions retarded acquisition of the task, although with further training the lesioned rats achieved a similar level of asymptotic performance to the control animals. The lesioned rats also exhibited marked nocturnal locomotor hyperactivity when tested under conditions of food deprivation, but not when tested satiated. The results indicate that bilateral striatal lesions induce mild deficits in the acquisition of the discrimination rules involved in performance of the delayed non-matching to position task. The present study does not support a role for the neostriatum in the specific mediation of short term memory in a operant DNMTP test.
先前的研究表明，背侧纹状体损伤会干扰与额叶皮质功能相关的各种认知任务的表现。为了拓展这些研究，我们调查了双侧纹状体损伤对在延迟位置不匹配范式中进行的短期记忆操作性测试习得的影响。在对动物进行不匹配任务训练之前，向其背侧纹状体注射鹅膏蕈氨酸或生理盐水作为对照。纹状体损伤延缓了任务的习得，不过随着进一步训练，损伤大鼠最终达到了与对照动物相似的渐近表现水平。当在食物剥夺条件下进行测试时，损伤大鼠还表现出明显的夜间运动性多动，但在饱食状态下测试时则没有。结果表明，双侧纹状体损伤会在延迟位置不匹配任务表现所涉及的辨别规则的习得方面诱发轻度缺陷。本研究不支持新纹状体在操作性延迟不匹配位置任务中对短期记忆的特定介导作用。
