Li C, Tian R, Zhu L, Li D, Feng Q, Gao X
Emergency Department, Beijing Army General Hospital.
Chin Med Sci J. 1995 Sep;10(3):161-4.
Radioimmunoassays were used to measure the concentration changes of plasma endothelin (ET) and atrial natriuretic peptide (ANP) during the onset and after termination of paroxysmal supraventricular tachycardia (SVT). 30 cases were reviewed and comparisons with 42 normal subjects were made. There are very significant differences (P < 0.0001) in the concentration changes of both plasma ET and ANP during the onset and 30 minutes after the termination of SVT. During the onset period of SVT, the plasma ET and ANP were markedly elevated and 30 minutes after its termination they were lowered significantly, but their concentrations were still 2-fold higher than those of the control group. As the biological effects of ANP and ET are antagonistic to each other, their parallel elevation and lowering of plasma concentrations during and after the termination of SVT reveal that these 2 hormones participate in the pathophysiological process of SVT. This phenomenon is possibly one of the homeostatic regulatory functions in the organism.
采用放射免疫分析法测定阵发性室上性心动过速（SVT）发作时及终止后血浆内皮素（ET）和心钠素（ANP）的浓度变化。回顾性分析30例患者，并与42例正常受试者进行比较。SVT发作时及终止后30分钟，血浆ET和ANP的浓度变化均有非常显著差异（P<0.0001）。SVT发作期，血浆ET和ANP显著升高，终止后30分钟显著降低，但其浓度仍比对照组高2倍。由于ANP和ET的生物学效应相互拮抗，SVT发作时及终止后血浆浓度的平行升高和降低表明这两种激素参与了SVT的病理生理过程。这种现象可能是机体稳态调节功能之一。
