Oliver J R, Twidale N, Lakin C, Cain M, Tonkin A M
Department of Medicine, Flinders Medical Centre, South Australia.
Br Heart J. 1988 Apr;59(4):458-62. doi: 10.1136/hrt.59.4.458.
Plasma concentrations of immunoreactive atrial natriuretic polypeptide were raised in 22 of 23 patients with paroxysmal supraventricular tachycardia and in all seven patients with atrial flutter. Plasma concentrations of atrial natriuretic polypeptide rose soon after the onset of supraventricular tachycardia. A sample taken 30 minutes after reversion to sinus rhythm (pharmacological or non-pharmacological) showed a significant fall in 19 of the 23 patients with paroxysmal supraventricular tachycardia and all seven patients with atrial flutter. Because atrial natriuretic polypeptide has powerful natriuretic and diuretic properties, an increase may contribute considerably to the polyuria that is often associated with episodes of supraventricular tachycardia.
23例阵发性室上性心动过速患者中有22例以及所有7例心房扑动患者的血浆免疫反应性心钠素浓度升高。室上性心动过速发作后不久，心钠素的血浆浓度即升高。在转复为窦性心律（药物或非药物转复）30分钟后采集的样本显示，23例阵发性室上性心动过速患者中的19例以及所有7例心房扑动患者的心钠素浓度显著下降。由于心钠素具有强大的利钠和利尿特性，其浓度升高可能在很大程度上导致了常与室上性心动过速发作相关的多尿。
