Hib J, Ponzio R
Centro de Investigaciones en Reproducción, Facultad de Medicina, Buenos Aires, Argentina.
Acta Physiol Pharmacol Ther Latinoam. 1995;45(1):27-33.
The effects of a pure antiandrogen flutamide and the 5 alpha-reductase inhibitor finestaride on both prenatal differentiation of prostate and external genitalia were studied in the rat. In control male offspring the mean value of anogenital distance was 3.1 +/- 0.24 mm, and in control female was 1.2 +/- 0.10 mm. In control male newborn rats, histological sections at cranial portion of the urethra revealed prostate bud formation. Male offspring prenatally exposed to 6 mg/Kg/day of flutamide had a significant decrease in anogenital distance, but no alteration in prostate bud formation. At higher dosages of flutamide, the external genitalia were virtually feminizated and the prostatic budding was completely inhibited. In male offspring treated 'in utero' with doses of finestaride of 2, 8 and 16 mg/Kg/day, the anogenital distance became progressively reduced, but complete abolition of prostate development never occurred. However, in male offspring given finestaride at a dose of 2 mg/Kg/day concomitantly with flutamide at a dose of 6 mg/Kg/day, prostate differentiation was completely abolished.
在大鼠中研究了纯抗雄激素氟他胺和5α-还原酶抑制剂非那雄胺对前列腺和外生殖器产前分化的影响。在对照雄性后代中，肛殖距的平均值为3.1±0.24毫米，对照雌性为1.2±0.10毫米。在对照雄性新生大鼠中，尿道头部的组织学切片显示前列腺芽形成。产前暴露于6毫克/千克/天氟他胺的雄性后代肛殖距显著减小，但前列腺芽形成无改变。在更高剂量的氟他胺作用下，外生殖器几乎女性化，前列腺芽生完全受到抑制。在子宫内用2、8和16毫克/千克/天剂量的非那雄胺处理的雄性后代中，肛殖距逐渐减小，但前列腺发育从未完全停止。然而，在以2毫克/千克/天剂量给予非那雄胺并同时以6毫克/千克/天剂量给予氟他胺的雄性后代中，前列腺分化完全被抑制。
