Brady S T, Sperry A O
Department of Cell Biology and Neuroscience, University of Texas Southwestern Medical Center, Dallas 75235-9111, USA.
Curr Opin Neurobiol. 1995 Oct;5(5):551-8. doi: 10.1016/0959-4388(95)80058-1.
The fact that multiple microtubule-based motors exist in brain inevitably raises questions about their function. Transcripts for at least seven kinesin superfamily genes and even more dynein heavy chain genes have been detected in brain cDNA libraries. The challenge now is to match their gene products to specific functions in cells of the nervous system. Recent studies have attempted to establish a function for each microtubule motor by using recombinant protein and immunochemical approaches.
大脑中存在多种基于微管的马达蛋白这一事实不可避免地引发了关于其功能的问题。在大脑cDNA文库中已检测到至少七个驱动蛋白超家族基因的转录本，甚至更多的动力蛋白重链基因的转录本。现在面临的挑战是将它们的基因产物与神经系统细胞中的特定功能相匹配。最近的研究试图通过使用重组蛋白和免疫化学方法来确定每种微管马达蛋白的功能。
