Perry V H, Bell M D, Brown H C, Matyszak M K
Department of Pharmacology, University of Oxford, UK.
Curr Opin Neurobiol. 1995 Oct;5(5):636-41. doi: 10.1016/0959-4388(95)80069-7.
Earlier studies on inflammation in the CNS have largely focused on conditions with an immune component. Recent evidence has emerged, however, that the innate, acute inflammatory response in the CNS parenchyma is quite unlike that in other tissues. The meninges and ventricular compartments show more typical responses, as does the parenchyma of the brain in immature animals. It is becoming apparent that the cells of the mononuclear phagocyte lineage dominate inflammatory responses in the CNS parenchyma.
早期对中枢神经系统炎症的研究主要集中在具有免疫成分的病症上。然而，最近有证据表明，中枢神经系统实质内的先天性急性炎症反应与其他组织中的炎症反应截然不同。脑膜和脑室区域表现出更典型的反应，未成熟动物大脑的实质也是如此。越来越明显的是，单核吞噬细胞谱系的细胞在中枢神经系统实质的炎症反应中占主导地位。
