P300 differences between sinistrals and dextrals.

The P3(00) event-related potential (ERP) was elicited in 20 left- and 20 normal right-handed young adult male subjects using a simple visual stimulus discrimination task. For left-compared to right-handed subjects, P3 amplitude was larger at anterior electrode sites for the target stimuli and larger overall for the novel visual stimuli; P3 latency was shorter for left-compared to right-handers for the target stimuli. The N1, P2, and N2 components demonstrated similar handedness effects. The relationships of ERP amplitude and handedness to anatomical variables and cognitive factors are discussed.