Takatsuki H, Umemura T, Nishimura J, Nawata H
Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Leuk Lymphoma. 1995 Apr;17(3-4):251-4. doi: 10.3109/10428199509056829.
Acute promyelocytic leukemia (APL) is characterized by the t(15;17) which involves the PML gene and the retinoic acid receptor alpha (RAR alpha) gene, and the subsequent PML/RAR alpha fusion gene is a key event in the leukemogenesis of APL. We found that the PML/RAR alpha fusion gene was expressed in both granulocytic/macrophage and erythroid colonies in a few patients with APL. In some instances of acute myelogenous leukemia (AML), erythrocytes or platelets also expressed the glucose-6-phosphate dehydrogenase (G-6-PD) isoenzymes which were detected in the leukemic cells. Some APL cells show basophilic and monocytoid differentiation and these findings suggest that the leukemic precursor of APL is derived from a more primitive cell stage than the promyelocyte. The precursor cells appear to be derived from heterogeneous levels.
急性早幼粒细胞白血病（APL）的特征是t(15;17)，它涉及早幼粒细胞白血病（PML）基因和维甲酸受体α（RARα）基因，随后形成的PML/RARα融合基因是APL白血病发生过程中的关键事件。我们发现，在少数APL患者的粒细胞/巨噬细胞集落和红系集落中均有PML/RARα融合基因表达。在某些急性髓系白血病（AML）病例中，红细胞或血小板也表达了在白血病细胞中检测到的葡萄糖-6-磷酸脱氢酶（G-6-PD）同工酶。一些APL细胞表现出嗜碱性和单核细胞样分化，这些发现表明，APL的白血病前体细胞来源于比早幼粒细胞更原始的细胞阶段。前体细胞似乎来源于不同水平。
