全反式维甲酸对髓外急性早幼粒细胞白血病的分化作用
Differentiation of extramedullary acute promyelocytic leukemia by all-trans-retinoic acid.
作者信息
Lederman C A, Weisberger J, Seiter K, Feldman E J
机构信息
Division of Oncology/Hematology, New York Medical College, Valhalla, New York 10595, USA.
出版信息
Leuk Lymphoma. 1995 Jun;18(1-2):189-93. doi: 10.3109/10428199509064942.
PMID:8580825
Abstract
The effect of all-trans-retinoic acid (ATRA) on extramedullary acute promyelocytic leukemia (APL) has not been fully delineated. We report an unusual case of APL in which a patient relapsed in the skin and central nervous system. Cytodifferentiation of leukemic cells from these extramedullary sites was demonstrated following treatment with ATRA.
摘要
全反式维甲酸（ATRA）对髓外急性早幼粒细胞白血病（APL）的影响尚未完全阐明。我们报告了1例不寻常的APL病例，该患者在皮肤和中枢神经系统复发。经ATRA治疗后，这些髓外部位的白血病细胞出现了细胞分化。
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