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乙醇利用调节蛋白：序列比对未发现其起源于醛脱氢酶和醇脱氢酶基因融合的证据。

Ethanol utilization regulatory protein: profile alignments give no evidence of origin through aldehyde and alcohol dehydrogenase gene fusion.

作者信息

Nicholas H B, Persson B, Jörnvall H, Hempel J

机构信息

Pittsburgh Supercomputing Center, Pennsylvania 15213, USA.

出版信息

Protein Sci. 1995 Dec;4(12):2621-4. doi: 10.1002/pro.5560041221.

DOI:10.1002/pro.5560041221
PMID:8580855
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2143040/
Abstract

The suggestion that the ethanol regulatory protein from Aspergillus has its evolutionary origin in a gene fusion between aldehyde and alcohol dehydrogenase genes (Hawkins AR, Lamb HK, Radford A, Moore JD, 1994, Gene 146:145-158) has been tested by profile analysis with aldehyde and alcohol dehydrogenase family profiles. We show that the degree and kind of similarity observed between these profiles and the ethanol regulatory protein sequence is that expected from random sequences of the same composition. This level of similarity fails to support the suggested gene fusion.

摘要

有人提出，来自曲霉的乙醇调节蛋白在进化上起源于醛脱氢酶基因和醇脱氢酶基因之间的基因融合（霍金斯·AR、兰姆·HK、拉德福德·A、摩尔·JD，1994年，《基因》146:145 - 158），我们通过醛脱氢酶和醇脱氢酶家族图谱分析对这一观点进行了验证。我们发现，这些图谱与乙醇调节蛋白序列之间观察到的相似程度和类型，与相同组成的随机序列所预期的情况相符。这种相似水平无法支持所提出的基因融合观点。

相似文献

1
Ethanol utilization regulatory protein: profile alignments give no evidence of origin through aldehyde and alcohol dehydrogenase gene fusion.乙醇利用调节蛋白：序列比对未发现其起源于醛脱氢酶和醇脱氢酶基因融合的证据。
Protein Sci. 1995 Dec;4(12):2621-4. doi: 10.1002/pro.5560041221.
2
Functional analysis of alcS, a gene of the alc cluster in Aspergillus nidulans.构巢曲霉中乙醇脱氢酶基因簇（alc）中的alcS基因的功能分析。
Fungal Genet Biol. 2006 Apr;43(4):247-60. doi: 10.1016/j.fgb.2005.12.008. Epub 2006 Mar 13.
3
Ethanol catabolism in Aspergillus nidulans: a model system for studying gene regulation.构巢曲霉中的乙醇分解代谢：一个用于研究基因调控的模型系统。
Prog Nucleic Acid Res Mol Biol. 2001;69:149-204. doi: 10.1016/s0079-6603(01)69047-0.
4
Specific binding sites for the activator protein, ALCR, in the alcA promoter of the ethanol regulon of Aspergillus nidulans.构巢曲霉乙醇调节子的alcA启动子中激活蛋白ALCR的特异性结合位点。
J Biol Chem. 1992 Oct 15;267(29):21146-53.
5
Regulation of alcR, the positive regulatory gene of the ethanol utilization regulon of Aspergillus nidulans.构巢曲霉乙醇利用调节子的正调控基因alcR的调控
Mol Microbiol. 1987 Nov;1(3):275-81. doi: 10.1111/j.1365-2958.1987.tb01933.x.
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Relationships between the ethanol utilization (alc) pathway and unrelated catabolic pathways in Aspergillus nidulans.构巢曲霉中乙醇利用（alc）途径与不相关分解代谢途径之间的关系。
Eur J Biochem. 2003 Sep;270(17):3555-64. doi: 10.1046/j.1432-1033.2003.03738.x.
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The cloning and sequencing of the alcB gene, coding for alcohol dehydrogenase II, in Aspergillus nidulans.构巢曲霉中编码乙醇脱氢酶II的alcB基因的克隆与测序。
Curr Genet. 1996 Jan;29(2):122-9. doi: 10.1007/BF02221575.
8
Comparison of the cis-acting control regions of two coordinately controlled genes involved in ethanol utilization in Aspergillus nidulans.构巢曲霉中参与乙醇利用的两个协同调控基因的顺式作用控制区域的比较。
Gene. 1987;51(2-3):205-16. doi: 10.1016/0378-1119(87)90309-x.
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The ethanol regulon in Aspergillus nidulans: characterization and sequence of the positive regulatory gene alcR.构巢曲霉中的乙醇调控子：正调控基因alcR的特性与序列
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10
Regulation of the aldehyde dehydrogenase gene (aldA) and its role in the control of the coinducer level necessary for induction of the ethanol utilization pathway in Aspergillus nidulans.构巢曲霉中醛脱氢酶基因（aldA）的调控及其在控制乙醇利用途径诱导所需共诱导剂水平中的作用。
J Biol Chem. 2001 Mar 9;276(10):6950-8. doi: 10.1074/jbc.M005769200. Epub 2000 Dec 1.

引用本文的文献

1
Deletion of the 389 N-terminal residues of the transcriptional activator AREA does not result in nitrogen metabolite derepression in Aspergillus nidulans.转录激活因子AREA的389个N端残基缺失不会导致构巢曲霉中氮代谢物阻遏解除。
J Bacteriol. 1998 Nov;180(21):5762-4. doi: 10.1128/JB.180.21.5762-5764.1998.

本文引用的文献

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Pattern recognition in genetic sequences.基因序列中的模式识别。
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Profile analysis.轮廓分析
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