Kapuściński J, Kuroszczyk J, Liniecki J, Bieńkiewicz M, Tuszyner K
Department of Nuclear Medicine, Medical University Lodz, Poland.
Int J Occup Med Environ Health. 1995;8(3):255-65.
Chronic damage to liver parenchyma was induced in rabbits by the long-term administration of carbon tetrachloride. The animals were serially sacrificed 3, 6 and 9 months after the start of intoxication, and examined histopathologically. The biological response was qualitatively assessed from results of histological studies, and measured utilizing series of typical biochemical indices of liver damage, 99mTc-mebrofenin (an-IDA-derivative) plasma clearance by the liver, and quantified indices of uptake and organ transfer of the compound. It was found that the plasma clearance and transfer parameters show association with chronic liver damage. The reduction of plasma 99mTc-mebrofenin clearance in intoxicated rabbits was also associated with changes in the biochemical indices of liver function and damage.
通过长期给予四氯化碳诱导家兔肝实质慢性损伤。在中毒开始后3、6和9个月对动物进行连续处死，并进行组织病理学检查。从组织学研究结果对生物学反应进行定性评估，并利用一系列典型的肝损伤生化指标、肝脏对99mTc-美布芬宁（一种IDA衍生物）的血浆清除率以及该化合物的摄取和器官转运量化指标进行测量。发现血浆清除率和转运参数与慢性肝损伤相关。中毒家兔血浆99mTc-美布芬宁清除率的降低也与肝功能和损伤的生化指标变化相关。
