Suzuki M, Mikami T, Matsumoto T, Suzuki S
Carbohydr Res. 1977 Feb;53(2):223-9. doi: 10.1016/s0008-6215(00)88090-8.
Dextran was modified by introduction of palmitoly and phosphate groups. The derivatives were analyzed by sequential periodate oxidation-sodium borohydride reduction. Only one of these derivatives showed a significant growth-inhibitory effect when administered alone, while a second derivative showed, in combination therapy with an ineffective dose of Mitomycin C, a marked synergistic effect.
通过引入棕榈酰基和磷酸基团对葡聚糖进行修饰。采用高碘酸盐氧化-硼氢化钠还原的顺序对衍生物进行分析。这些衍生物中只有一种单独给药时显示出显著的生长抑制作用，而另一种衍生物在与无效剂量的丝裂霉素C联合治疗时显示出明显的协同效应。
