Yang C S, Lin N N, Liu L, Tsai P J, Kuo J S
Department of Medical Research, Taichung Veterans General Hospital, Taiwan, R.O.C.
Brain Res. 1995 Nov 6;698(1-2):237-40. doi: 10.1016/0006-8993(95)00992-y.
The effect of lowered brain glutathione content on the glutamate release following cerebral ischemia was investigated. Diethylmaleate (4 mmol/kg, i.p.), a commonly used chemical reagent for tissue glutathione depletion, significantly reduced the ischemia-induced glutamate release. The release of another excitatory amino acid aspartate was not affected by the diethylmaleate administration. These results suggested that part of the elevated glutamate content induced by ischemia might result from the cellular GSH.
研究了脑谷胱甘肽含量降低对脑缺血后谷氨酸释放的影响。二乙基马来酸酯（4 mmol/kg，腹腔注射）是一种常用的使组织谷胱甘肽耗竭的化学试剂，它能显著降低缺血诱导的谷氨酸释放。另一种兴奋性氨基酸天冬氨酸的释放不受二乙基马来酸酯给药的影响。这些结果表明，缺血诱导的谷氨酸含量升高的部分原因可能是细胞内的谷胱甘肽。
