Hurley J K, Kirkpatrick S E, Pitlick P T, Friedman W F, Mendoza S A
Circ Res. 1977 Jun;40(6):557-60. doi: 10.1161/01.res.40.6.557.
Fetal and maternal glomerular filtration rate (GFR), renal plasma flow (RPF), urine volume, sodium excretion, and fractional sodium reabsorption were measured in a chronically instrumented sheep preparation. Fetal GFR was essentially stable between 110 and 135 days of gestation (term = 147 days). There was a significant increase in GFR after 135 days. After the infusion of 50 ml of normal saline over a 30-minute period, fetal GFR and sodium excretion increased significantly. Fractional sodium reabsorption was significantly decreased. Thus, the fetus is capable of responding to volume expansion with saline with an increase in GFR and a decrease in fractional sodium reabsorption. After the infusion of 1000 ml of normal saline into the ewe in 1 hour, maternal GFR and RPF rose significantly. Sodium excretion rose 6-fold and fractional sodium reabsorption fell significantly. After the infusion of saline into the ewe, there was no change in fetal GFR, RPF, sodium excretion, urine volume, or fractional sodium reabsorption. Since there were no changes in fetal renal function after maternal volume expansion with saline there was no evidence for the transplacental passage of a natriuretic factor from ewe to fetus.
在一个长期植入仪器的绵羊模型中，测量了胎儿和母体的肾小球滤过率（GFR）、肾血浆流量（RPF）、尿量、钠排泄量以及钠重吸收分数。胎儿GFR在妊娠110至135天之间基本稳定（足月为147天）。135天后GFR显著增加。在30分钟内输注50毫升生理盐水后，胎儿GFR和钠排泄量显著增加。钠重吸收分数显著降低。因此，胎儿能够通过增加GFR和降低钠重吸收分数来对生理盐水引起的容量扩张做出反应。在1小时内向母羊输注1000毫升生理盐水后，母体GFR和RPF显著升高。钠排泄量增加了6倍，钠重吸收分数显著下降。向母羊输注生理盐水后，胎儿的GFR、RPF、钠排泄量、尿量或钠重吸收分数均无变化。由于母体用生理盐水进行容量扩张后胎儿肾功能没有变化，因此没有证据表明利尿因子可经胎盘从母羊传递给胎儿。
