Jarvis D, Luczynska C, Chinn S, Burney P
Department of Public Health Medicine, United Medical School, Guys', London, UK.
Clin Exp Allergy. 1995 Nov;25(11):1083-91. doi: 10.1111/j.1365-2222.1995.tb03255.x.
Smoking has been identified as a risk factor for atopy but there are difficulties in interpreting many of the previous studies because the subjects who have been studied have not been representative of the entire population and because there is confounding between gender and smoking.
To investigate the association of age, gender and smoking with total IgE and specific IgE to house dust mite, grass and cat.
A stratified random sample of 20-44 year olds living in three centres in East Anglia and registered with a local general practitioner had blood taken for total immunoglobulin E (IgE) and specific IgE. A smoking history was obtained from a structured interviewer-led questionnaire.
Among non-smokers geometric mean total IgE was higher in men than women but unrelated to age. Smoking explained less than 1% of the variation in total IgE. Smoking was associated with an increased risk of sensitization to house dust mite (odds ratio 1.59; 95% confidence interval 1.02-2.48) but a decreased risk of sensitization to grass (odds ratio 0.45; 95% confidence interval 0.28-0.71) and cat (odds ratio 0.47; 0.24-0.94).
Men aged 20-44 years have higher total IgE levels than women of the same age. In young adults smoking explains little of the variation in total IgE and its association with sensitization to common allergens varies between allergens.
吸烟已被确定为特应性的一个风险因素，但以往许多研究的解读存在困难，因为所研究的对象不能代表整个人口，且性别与吸烟之间存在混杂因素。
调查年龄、性别和吸烟与总IgE以及对屋尘螨、草和猫的特异性IgE之间的关联。
对居住在东安格利亚三个中心、在当地全科医生处注册的20 - 44岁人群进行分层随机抽样，采集血液检测总免疫球蛋白E（IgE）和特异性IgE。通过结构化访谈问卷获取吸烟史。
在非吸烟者中，男性的几何平均总IgE高于女性，但与年龄无关。吸烟对总IgE变异的解释不足1%。吸烟与对屋尘螨致敏风险增加相关（比值比1.59；95%置信区间1.02 - 2.48），但与对草（比值比0.45；95%置信区间0.28 - 0.71）和猫（比值比0.47；0.24 - 0.94）致敏风险降低相关。
20 - 44岁男性的总IgE水平高于同龄女性。在年轻人中，吸烟对总IgE变异的解释作用不大，且其与对常见变应原致敏的关联因变应原而异。
