对氨基苯甲酸（PABA）的甘氨酸结合作用：一项肝功能定量检测
Glycine conjugation of para-aminobenzoic acid (PABA): a quantitative test of liver function.
作者信息
Furuya K N, Durie P R, Roberts E A, Soldin S J, Verjee Z, Yung-Jato L, Giesbrecht E, Ellis L
机构信息
Research Institute, Hospital for Sick Children, University of Toronto, Ontario, Canada.
出版信息
Clin Biochem. 1995 Oct;28(5):531-40. doi: 10.1016/0009-9120(95)00040-g.
OBJECTIVE
To evaluate glycine conjugation of para-aminobenzoic acid (PABA) to the hippurated metabolites, para-aminohippuric acid (PAHA), and para-acetamidohippuric acid (PAAHA) as a quantitative liver function test in patients with liver disease.
DESIGN AND METHODS
Serum concentrations of PABA and metabolites were measured by high pressure liquid chromatography in 24 controls and 50 patients with hepatobiliary disease.
RESULTS
Hippurate formation was significantly decreased in all patient groups with chronic liver disease versus controls. The hippurate ratio (% hippurated metabolites formed) correlated with severity of disease, serum albumin, and factor VII concentrations. PAHA concentration was a better prognostic indicator than factor VII concentrations in patients with acute liver disease; concentrations of zero correctly predicted a poor outcome in patients with fulminant liver failure.
CONCLUSIONS
Glycine conjugation of PABA may be useful as a quantitative liver function test in patients with hepatobiliary disease and as a prognostic index in patients with fulminant liver failure.
目的
评估对氨基苯甲酸（PABA）与马尿酸代谢产物对氨基马尿酸（PAHA）和对乙酰氨基马尿酸（PAAHA）的甘氨酸结合作用，作为肝病患者的定量肝功能试验。
设计与方法
采用高压液相色谱法测定24名对照者和50名肝胆疾病患者血清中PABA及其代谢产物的浓度。
结果
与对照组相比，所有慢性肝病患者组的马尿酸盐形成均显著减少。马尿酸盐比率（形成的马尿酸化代谢产物百分比）与疾病严重程度、血清白蛋白和凝血因子VII浓度相关。在急性肝病患者中，PAHA浓度比凝血因子VII浓度是更好的预后指标；在暴发性肝衰竭患者中，PAHA浓度为零可正确预测不良预后。
结论
PABA的甘氨酸结合作用可用作肝胆疾病患者的定量肝功能试验以及暴发性肝衰竭患者的预后指标。
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