Timon C I, Dardick I, Panzarella T, Thomas J, Ellis G, Gullane P
Department of Otolaryngology, Head and Neck Surgery, Toronto Hospital, Ottawa, Canada.
Clin Otolaryngol Allied Sci. 1995 Oct;20(5):396-401. doi: 10.1111/j.1365-2273.1995.tb00069.x.
The biological behaviour of acinic cell carcinomas, even if well differentiated, is unpredictable. We studied 45 patients with acinic cell carcinoma followed-up from 10 to 379 months (5 year recurrence-free and survival rate of 69% and 81% respectively), and compared clinico-pathological parameters with outcome. The presence of a predominately solid architecture was strongly associated with a poor outcome (P < 0.01) and this was the only independent prognostic variable when log rank testing was performed. Tumour size (> 2.75 cm) was a significant predictor of recurrent deep parotid lobe involvement, the presence of cervical nodal disease and lymphocytic infiltration, although not significant, factors showed a tendency towards recurrence. For acinic cell carcinoma, the predominant solid architecture would appear to be a strong predictor of recurrence.
腺泡细胞癌的生物学行为，即使是高分化的，也是不可预测的。我们研究了45例腺泡细胞癌患者，随访时间为10至379个月（5年无复发生存率和生存率分别为69%和81%），并将临床病理参数与预后进行了比较。主要为实性结构与不良预后密切相关（P < 0.01），在进行对数秩检验时，这是唯一的独立预后变量。肿瘤大小（> 2.75 cm）是腮腺深叶复发受累、颈部淋巴结疾病和淋巴细胞浸润的重要预测指标，尽管不显著，但这些因素显示出复发倾向。对于腺泡细胞癌，主要的实性结构似乎是复发的有力预测指标。
