Rudolph R, Gray A P, Leipold H W
Cornell Vet. 1977 Apr;67(2):254-64.
The intracutaneous cornifying epithelioma ("keratoacanthoma") of dogs was compared with keratoacanthoma of man based on findings in the literature and in house studies. The two tumors differ at the following points: epithelium of origin, rate of growth, infiltration, spontaneous involution, breed predisposition (Norwegian Elkhound, generalized form), occurrence in dogs at a younger or middle age. The development of this tumor in dogs seems to be comparable with the development of so-called keratoacanthoma in Mastomys natalensis, which is virus-induced. Further investigations have been initiated to uncover the possible virus nature of the intracutaneous cornifying epthelioma (so-called keratoacanthoma) in dogs.
基于文献资料和内部研究结果，对犬的皮内角质化上皮瘤（“角化棘皮瘤”）与人的角化棘皮瘤进行了比较。这两种肿瘤在以下方面存在差异：起源上皮、生长速度、浸润情况、自发消退、品种易感性（挪威猎麋犬，全身性）、在犬类中的发病年龄（年轻或中年）。犬类中这种肿瘤的发生发展似乎与南非多乳鼠中所谓由病毒诱导的角化棘皮瘤的发生发展类似。已展开进一步调查，以揭示犬皮内角质化上皮瘤（所谓的角化棘皮瘤）可能的病毒本质。
