[重复剂量活性炭治疗卡马西平、地高辛和乙酰水杨酸所致急性中毒]

[Treatment of acute poisoning caused by carbamazepine, digoxin, and acetylsalicylic acid, with repeated doses of activated charcoal].

作者信息

Montoya-Cabrera M A, Escalante-Galindo P, Sauceda-García J M, Márquez-Enríquez L M, González-Cabello H, Flores-Alvarez E

机构信息

Departamento de Urgencias y Toxicología, Hospital de Pediatría, Centro Médico Nacional Siglo XXI (IMSS).

出版信息

Gac Med Mex. 1995 May-Jun;131(3):349-54.

PMID:8582575

Abstract

Twelve pediatric patients with acute poisonings caused by carbamazepine, digoxin and acetylsalicylic acid were treated with multiple doses of activated charcoal combined with a saline cathartic (adsorption surface of activated charcoal nearly 950 m2/g). This procedure was effective to shorten the plasmatic levels of the drugs, besides the clinical improvement of the poisoned patients. The average initial and final levels of the drugs were: carbamazepine 21.64 and 0.9 micrograms/ml (lowering 95.81%, p < 0.05), digoxin 5.14 and 1.1 ng/ml (lowering 78.6%, P < 0.05) and acetylsalicylic acid 418.5 and 57.5 micrograms/ml, respectively, (lowering 86.3%, p < 0.05). These results suggest the usefulness of activated charcoal in the clearance of the four overdosed drugs.

摘要

12名因卡马西平、地高辛和乙酰水杨酸导致急性中毒的儿科患者接受了多剂量活性炭联合盐类泻药的治疗（活性炭的吸附表面积接近950平方米/克）。除中毒患者临床症状改善外，该治疗方法还能有效缩短药物的血浆水平。药物的平均初始和最终水平分别为：卡马西平21.64和0.9微克/毫升（降低95.81%，p<0.05），地高辛5.14和1.1纳克/毫升（降低78.6%，P<0.05），乙酰水杨酸418.5和57.5微克/毫升（降低86.3%，p<0.05）。这些结果表明活性炭在清除这四种过量服用药物方面是有用的。