三名青少年的卡马西平中毒通过血液透析和血液灌流进行治疗。

Carbamazepine poisoning managed with haemodialysis and haemoperfusion in three adolescents.

作者信息

Bek Kenan, Koçak Sule, Ozkaya Ozan, Yilmaz Yunus, Aydin Omer Faruk, Taşdöven Cigdem Sag

机构信息

Department of Paediatric Nephrology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.

出版信息

Nephrology (Carlton). 2007 Feb;12(1):33-5. doi: 10.1111/j.1440-1797.2006.00663.x.

DOI:10.1111/j.1440-1797.2006.00663.x

PMID:17295658

Abstract

Carbamazepine is a widely used antiepileptic agent. Accidental or suicidal overdose in children is not uncommon. Acute toxicity is associated with seizures, coma, arrhythmias and death in severe cases. Here we report three adolescents with carbamzepine overdose, two managed with standard low-flux haemodialysis and one with charcoal haemoperfusion. Our report emphasizes that haemodialysis might be a cheaper and easier alternative for carbamazepine overdose in milder cases, with fewer side-effects than haemoperfusion.

摘要

卡马西平是一种广泛使用的抗癫痫药物。儿童意外或自杀性过量服用并不罕见。急性中毒在严重情况下会导致癫痫发作、昏迷、心律失常甚至死亡。在此，我们报告三例青少年卡马西平过量服用病例，其中两例采用标准低通量血液透析治疗，一例采用活性炭血液灌流治疗。我们的报告强调，对于症状较轻的卡马西平过量服用病例，血液透析可能是一种更便宜、更简便的治疗方法，且副作用比血液灌流更少。