Alloatti S, Molino A, Manes M, Bonfant G, Bosticardo G M
Nephrology and Dialysis Unit, Ospedale della Valle d'Aosta, Aosta, Italy.
Int J Artif Organs. 1995 Sep;18(9):548-52.
The outputs of a new on-line dialysate urea monitor (UM) were compared to a urea kinetic model (UKM) and to dialysis direct quantification (DDQ) in 13 patients. As for urea extraction and predialysis urea level, a good degree of correspondence was found between UM and laboratory data. Kt/VUM (1.21) is intermediate between Kt/VUKM (1.28) and Kt/VUKM using the post-rebound urea value (1.14) or Kt/VDDQ (1.14). Passing and Bablok regression analysis indicated no systematic error between Kt/VUM and Kt/VDDQ. The percentage differences in nPCR by UM, UKM and DDQ were not significant, but the standard deviations were wide. The UM approach is very simple and practical, avoiding blood sampling, laboratory analysis and data handling. It is reliable enough for clinical practice. Compared with traditional urea kinetics, Kt/V computation by a mathematical elaboration of the dialysate urea profile drawn from several points theoretically invites fewer errors due to the analytical procedure.
在13例患者中，将一种新型在线透析液尿素监测仪（UM）的输出结果与尿素动力学模型（UKM）以及透析直接定量法（DDQ）进行了比较。关于尿素清除率和透析前尿素水平，UM与实验室数据之间存在良好的对应程度。UM计算的Kt/V值（1.21）介于UKM计算的Kt/V值（1.28）以及使用反跳后尿素值计算的Kt/VUKM值（1.14）或DDQ计算的Kt/V值（1.14）之间。通过与Bablok回归分析表明，Kt/VUM与Kt/VDDQ之间不存在系统误差。UM、UKM和DDQ计算的nPCR的百分比差异不显著，但标准差较大。UM方法非常简单实用，避免了采血、实验室分析和数据处理。它对于临床实践来说足够可靠。与传统尿素动力学相比，通过对从多个点绘制的透析液尿素曲线进行数学处理来计算Kt/V，理论上由于分析过程导致的误差较少。
