Carayon P, Bouaboula M, Loubet J F, Bourrie B, Petitpretre G, Le Fur G, Casellas P
Immunology Department, Sanofi Recherche, Montpellier, France.
Int J Immunopharmacol. 1995 Sep;17(9):753-61. doi: 10.1016/0192-0561(95)00066-b.
SR 31747 is a sigma ligand which prevents the development of acute graft-versus-host reaction (GvHR) in hybrid B6D2F1 mice injected with C57BL/6 parental spleen cells. In the present study, we showed that this drug dramatically impaired the GvHR-associated increase in the numbers of both B-lymphocytes and polymorphonuclear cells (PMNs) in the spleen. Because SR 31747 blocked the GvHR-induced expression of both interleukin-2 and transferrin receptors on T-lymphocytes, it is very likely that this molecule prevented the disease through an inhibition of T-lymphocyte activation. Cytokine messenger RNA analyses on spleen cells revealed that SR 31747 blocked IFN-gamma and GM-CSF but not IL-4 transcription. These effects, which are different from those observed with either cyclosporin-A or dexamethasone, strongly suggest that SR 31747 preferentially inhibits the Th1 lymphocyte subset.
SR 31747是一种西格玛配体，可防止向注射了C57BL / 6亲代脾细胞的杂交B6D2F1小鼠发生急性移植物抗宿主反应（GvHR）。在本研究中，我们表明该药物显著损害了脾脏中与GvHR相关的B淋巴细胞和多形核细胞（PMN）数量的增加。由于SR 31747阻断了GvHR诱导的T淋巴细胞上白细胞介素-2和转铁蛋白受体的表达，很可能该分子通过抑制T淋巴细胞活化来预防疾病。对脾细胞的细胞因子信使RNA分析显示，SR 31747阻断了IFN-γ和GM-CSF但不阻断IL-4转录。这些不同于环孢菌素A或地塞米松所观察到的效应，强烈表明SR 31747优先抑制Th1淋巴细胞亚群。
