Ferrandina G, Lanzone A, Scambia G, Caruso A, Panici P B, Mancuso S
Department of Obstetrics and Gynecology, Catholic University, Largo A. Gemelli, Rome, Italy.
Hum Reprod. 1995 Jul;10(7):1845-9. doi: 10.1093/oxfordjournals.humrep.a136189.
Epidermal growth factor receptor concentrations (EGFR) in placentae and fetal membranes from 25 normal and 25 hypertension-complicated pregnancies were analysed by a radioreceptor technique. Higher EGFR concentrations were found in placentae from hypertension-complicated pregnancies than in those from normal pregnancies (median 125.0 fmol/mg protein, range: 33.4-190.7 versus median 50.3 fmol/mg protein, range 21.4-184.0) (P = 0.0002). EGFR concentrations were significantly lower in fetal membranes than in placental tissue, both in normal membranes (median 31.7, range 4.8-92.0 versus median 50.3, range 21.4-184.0) (P = 0.0004) and in hypertension-complicated pregnancies (median 65.0, range 16.8-125.0 versus median 125.0, range 33.4-190.7) (P = 0.0001). A statistically significant inverse correlation between EGFR concentrations and gestational age was found in placentae (r = 0.53, P = 0.0061) and fetal membranes (r = 0.56, P = 0.0032) from hypertension-complicated pregnancies. Multiple regression analyses demonstrated that hypertensive disease is more closely associated with EGFR concentrations than gestational age and fetal weight in placental tissue and fetal membranes. Our findings suggest that hypertensive disorders in pregnancy are associated with elevated EGFR concentrations in both the placenta and fetal membranes.
采用放射受体技术分析了25例正常妊娠和25例并发高血压妊娠的胎盘及胎膜中的表皮生长因子受体浓度（EGFR）。发现并发高血压妊娠的胎盘EGFR浓度高于正常妊娠胎盘（中位数125.0 fmol/mg蛋白，范围：33.4 - 190.7，而正常妊娠胎盘的中位数为50.3 fmol/mg蛋白，范围21.4 - 184.0）（P = 0.0002）。无论是正常胎膜（中位数31.7，范围4.8 - 92.0，而胎盘组织中位数为50.3，范围21.4 - 184.0）（P = 0.0004）还是并发高血压妊娠的胎膜（中位数65.0，范围16.8 - 125.0，而胎盘组织中位数为125.0，范围33.4 - 190.7）（P = 0.0001），胎膜中的EGFR浓度均显著低于胎盘组织。在并发高血压妊娠的胎盘（r = 0.53，P = 0.0061）和胎膜（r = 0.56，P = 0.0032）中，EGFR浓度与孕周之间存在统计学上显著的负相关。多元回归分析表明，在胎盘组织和胎膜中，高血压疾病与EGFR浓度的关联比与孕周和胎儿体重的关联更为密切。我们的研究结果表明，妊娠期高血压疾病与胎盘和胎膜中EGFR浓度升高有关。
