Hoek A, Broekmans F J, Verheijen R H, Schats R
Department of Obstetrics and Gynaecology, Free University Hospital, Amsterdam, The Netherlands.
Hum Reprod. 1995 Jul;10(7):1864-5. doi: 10.1093/oxfordjournals.humrep.a136193.
A patient is presented with an advanced interstitial pregnancy, diagnosed by transvaginal ultrasound and confirmed by laparoscopy. Amenorrhoea at the time of diagnosis was 57 days. Methotrexate was given systemically (4 x 50 mg i.m.). Because of persisting viability of the fetus, systemic methotrexate treatment was followed by local instillation of methotrexate into the gestational sac (50 mg). Follow-up revealed rapid human chorionic gonadotrophin regression but slow regression of fetal remnants.
