De Bruyne F, Tutschek B, Hucke J, Crombach G
Department of Obstetrics and Gynaecology, Heinrich Heine University, Düsseldorf, Germany.
Gynecol Obstet Invest. 1998 Aug;46(2):133-8. doi: 10.1159/000010017.
We present a case of an intact interstitial pregnancy at 6 postmenstrual weeks and 4 days, which was successfully treated by combined local and systemic methotrexate administration. The embryonic cardiac activity stopped within 1 min after uneventful ultrasound-guided puncture and methotrexate instillation of the chorionic sac. While the beta-hCG serum values returned to normal 59 days after local, and 52 days after systemic treatment, the echogenic lesion has reduced in size by 50%, but is still sonographically detectable 7 months after the procedure. This report shows that medical treatment of interstitial pregnancy may be an effective alternative to the surgical approach.
我们报告一例月经周期6周零4天的完整间质部妊娠病例，该病例通过局部和全身联合应用甲氨蝶呤成功治疗。在超声引导下对绒毛膜囊进行顺利穿刺并注入甲氨蝶呤后1分钟内，胚胎心脏活动停止。虽然局部治疗后59天、全身治疗后52天血清β-hCG值恢复正常，但回声性病变大小缩小了50%，但在手术后7个月超声检查仍可检测到。本报告表明，间质部妊娠的药物治疗可能是手术治疗的一种有效替代方法。
