Vasudeva N, Anand C
Department of Anatomy, All India Institute of Medical Sciences in New Delhi.
J Am Coll Health. 1996 Jan;44(4):177-9. doi: 10.1080/07448481.1996.9937526.
Formaldehyde (FA) is a potential carcinogen and mutagen. In addition to inducing genotoxic effects in subhuman laboratory tests, FA has been found to be mutagenic to cultured human cells. Evidence regarding the genotoxic potential of FA on exposed individuals at occupational levels is insufficient and conflicting. The authors of this study examined chromosomal aberrations in peripheral blood lymphocytes from a group of 30 medical students exposed to FA for 15 months in a gross anatomy dissection laboratory. The results were compared with similar analyses from 30 off-site, matched, unexposed controls. At average exposures of less than 1 ppm, 72-hour lymphocyte cultures of the study cohort did not reveal any difference in the incidences of chromosomal aberrations among the exposed and the control group by conventional Giemsa staining and G-banding.
甲醛（FA）是一种潜在的致癌物和诱变剂。除了在亚人类实验室测试中诱导遗传毒性效应外，还发现FA对培养的人类细胞具有致突变性。关于职业水平接触FA的个体的遗传毒性潜力的证据不足且相互矛盾。本研究的作者检查了一组30名医科学生的外周血淋巴细胞中的染色体畸变情况，这些学生在大体解剖实验室中接触FA达15个月。将结果与30名来自非现场、匹配的未接触对照组的类似分析进行了比较。在平均暴露水平低于1 ppm的情况下，通过传统吉姆萨染色和G显带法，研究队列的72小时淋巴细胞培养未显示暴露组和对照组之间染色体畸变发生率有任何差异。
