Shankaran K, Desai H G
J Clin Gastroenterol. 1995 Sep;21(2):82-4.
Human and animal stomachs were considered the only reservoirs of Helicobacter pylori until it was identified in human dental plaque (DP). H. pylori is infrequent in populations from developed countries, but is widespread in those from developing countries. The failure of triple drug therapy to clear H. pylori from DP, despite its clearance from gastric mucosa, raised the possibility of DP as a permanent reservoir of H. pylori and a potential source of reinfection of gastric mucosa. Attempts should be made to eradicate H. pylori both from the gastric mucosa and from DP to ensure a permanent cure of duodenal ulcer. Unfortunately, all attempts to eradicate H. pylori from DP have failed.
在幽门螺杆菌在人类牙菌斑（DP）中被发现之前，人类和动物的胃部被认为是幽门螺杆菌的唯一储存库。幽门螺杆菌在发达国家人群中不常见，但在发展中国家人群中广泛存在。尽管三联药物疗法能清除胃黏膜中的幽门螺杆菌，但却无法清除牙菌斑中的幽门螺杆菌，这增加了牙菌斑作为幽门螺杆菌永久储存库以及胃黏膜再次感染潜在来源的可能性。应尝试从胃黏膜和牙菌斑中根除幽门螺杆菌，以确保十二指肠溃疡得到根治。不幸的是，所有从牙菌斑中根除幽门螺杆菌的尝试都失败了。
