Ogunbodede E O, Lawal O O, Lamikanra A, Okeke I N, Rotimi O, Rasheed A A
Departments of Preventive Dentistry, Surgery, Pharmaceutics, and Morbid Anatomy, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria.
Trop Gastroenterol. 2002 Jul-Sep;23(3):127-33.
Presence of helicobacter pylori (H.Pylori) in the dental plaques may be associated with the presence of the same organism in gastric mucosa.
To assess and compare the prevalence of H. pylori in dental plaques and gastric mucosa of dyspeptic Nigerians.
Sixty-six consecutive patients undergoing endoscopy for investigation of dyspepsia were included in the study. A predesigned questionnaire was used to collect information on socio-demographic and other factors. Each patient also had clinical dental examination. Dental plaque scrapping was collected before endoscopy for helicobacter pylori culture, and at endoscopy, two gastric biopsy specimens were taken for culture and histology.
The mean age (+/- SD) of the patients was 44.8 (+/- 17.4) years (range 5 to 80 years). The positivity rate of helicobacter pylori in gastric biopsy was 35 of 66 (53.0%) while the same for dental plaque was 46 of 66 (69.7%). The correlation (Spearman's) between gastric mucosa and dental plaque colonization with helicobactor pylori was significant (R = 0.30, P = 0.01). When concordant positivity of gastric biopsy culture and histology was taken as diagnostic, the sensitivity of dental plaque culture was found to be 82.9% and the specificity was 45.2%.
This study revealed that helicobactor pylori has a high prevalence in the dental plaque of the population that we have studied and may therefore be of potential relevance in screening for such infection.
牙菌斑中幽门螺杆菌（H.Pylori）的存在可能与胃黏膜中该菌的存在有关。
评估并比较消化不良的尼日利亚人牙菌斑和胃黏膜中幽门螺杆菌的患病率。
本研究纳入了66例因消化不良接受内镜检查的连续患者。使用预先设计的问卷收集社会人口统计学和其他因素的信息。每位患者还接受了临床牙科检查。在内镜检查前采集牙菌斑刮片用于幽门螺杆菌培养，在内镜检查时，采集两份胃活检标本用于培养和组织学检查。
患者的平均年龄（±标准差）为44.8（±17.4）岁（范围5至80岁）。胃活检中幽门螺杆菌的阳性率为66例中的35例（53.0%），而牙菌斑中的阳性率为66例中的46例（69.7%）。胃黏膜与牙菌斑中幽门螺杆菌定植之间的相关性（Spearman相关性）显著（R = 0.30，P = 0.01）。以胃活检培养和组织学的一致阳性作为诊断标准时，发现牙菌斑培养的敏感性为82.9%，特异性为45.2%。
本研究表明，在我们所研究的人群中，幽门螺杆菌在牙菌斑中的患病率很高，因此可能在这种感染的筛查中具有潜在相关性。
