松果体对大鼠肝脏再生的影响。

The effect of the pineal gland on liver regeneration in rats.

作者信息

Abbasoglu O, Berker M, Ayhan A, Palaoglu S, Sayek I

机构信息

Department of General Surgery, Hacettepe University School of Medicine, Ankara, Turkey.

出版信息

J Hepatol. 1995 Nov;23(5):578-81. doi: 10.1016/0168-8278(95)80065-4.

DOI:10.1016/0168-8278(95)80065-4

PMID:8583147

Abstract

BACKGROUND/AIMS: We investigated the influence of pinealectomy on liver regeneration after partial hepatectomy in rats.

METHODS

Thirty rats were allocated into four groups as follows: group 1 in which no operation was done (control), group 2 in which only midline scalp incision and craniotomy was performed (sham operation), group 3 in which pinealectomy was performed and group 4 in which the rats underwent pinealectomy and pineal transplantation. Eight weeks later all the rats underwent 70% hepatectomy.

RESULTS

Hepatic regenerative capacity was observed 24 h after PH by bromodeoxyuridine incorporation into DNA and the mitotic index of hepatocytes. The bromodeoxyuridine labeling indices were 45.4, 35.8, 19.9 and 36.8 in groups 1, 2, 3 and 4, respectively. The mitotic indices of the same groups were 31.2, 28.7, 8.3 and 13.4, respectively. Both the bromodeoxyuridine labeling and mitotic indices were significantly lower in the pinealectomized rats than in the control and sham operation groups.

CONCLUSIONS

These results suggest that the pineal gland stimulates liver regeneration after partial hepatectomy in rats.

摘要

背景/目的：我们研究了松果体切除对大鼠部分肝切除术后肝再生的影响。

方法

30只大鼠被分为四组如下：第1组未进行手术（对照组），第2组仅进行中线头皮切口和开颅手术（假手术组），第3组进行松果体切除术，第4组大鼠接受松果体切除和松果体移植。八周后，所有大鼠均接受70%肝切除术。

结果

通过将溴脱氧尿苷掺入DNA以及肝细胞的有丝分裂指数观察部分肝切除术后24小时的肝再生能力。第1、2、3和4组的溴脱氧尿苷标记指数分别为45.4、35.8、19.9和36.8。相同组的有丝分裂指数分别为31.2、28.7、8.3和13.4。松果体切除的大鼠中溴脱氧尿苷标记指数和有丝分裂指数均显著低于对照组和假手术组。