Cucchiara S, Bassotti G, Castellucci G, Minella R, Betti C, Fusaro C, Morelli A, Bertotto A, Auricchio S
Dipartimento di Pediatria, Università degli Studi di Napoli, Italy.
J Pediatr Gastroenterol Nutr. 1995 Nov;21(4):435-42. doi: 10.1097/00005176-199511000-00011.
Although from the clinical point of view a GI motor disorder can be suspected in celiac disease, objective evidence for this is still lacking. We therefore conducted a study on children with active celiac disease to detect possible GI motor abnormalities in this disease. Fourteen children (age range, 1-13 years) were studied; they underwent fasting and fed manometric recordings in the gastroduodenojejunal area. Four patients were restudied after a 6-month gluten-free diet. Data were compared with those obtained in eight control children. As compared with controls, celiac disease patients showed a shorter duration of activity fronts (p < 0.01) and a significant (p < 0.01) reduction of the postprandial antral motility index; furthermore, > 90% of the patients displayed marked fasting and/or fed motor abnormalities, suggesting a neuropathic disorder. Interestingly, gut dysmotilities disappeared in the four subjects reassessed after the gluten-free diet. It is concluded that celiac disease frequently affects the motor behavior of the gut and that its effects may be reversed by appropriate diet.
尽管从临床角度来看，乳糜泻可能存在胃肠道运动障碍，但目前仍缺乏相关客观证据。因此，我们对患有活动性乳糜泻的儿童进行了一项研究，以检测该疾病中可能存在的胃肠道运动异常。研究了14名儿童（年龄范围为1至13岁）；他们在禁食和进食状态下对胃十二指肠空肠区域进行了测压记录。4名患者在接受6个月无麸质饮食后再次进行研究。将数据与8名对照儿童的数据进行比较。与对照组相比，乳糜泻患者的活动波持续时间较短（p < 0.01），餐后胃窦运动指数显著降低（p < 0.01）；此外，超过90%的患者表现出明显的禁食和/或进食运动异常，提示存在神经病变。有趣的是，在无麸质饮食后重新评估的4名受试者中，肠道运动障碍消失了。得出的结论是，乳糜泻经常影响肠道的运动行为，并且通过适当的饮食其影响可能会逆转。
