Jain C P, Vyas S P
Department of Pharmaceutical Sciences, Dr H. S. Gour Vishwavidyalaya, Sagar, India.
J Microencapsul. 1995 Jul-Aug;12(4):401-7. doi: 10.3109/02652049509087252.
Niosomes (non-ionic, surfactant-based vesicles) containing rifampicin of 8-15 microns in diameter were prepared using Span-85 and cholesterol in various molar fractions. The process variables that could affect the physical characteristics of niosomes and in vitro release of the drug from the niosomes were studied and optimized. In vivo distribution studies of the prepared niosomes found that 65% of the drug could be localized in the lungs by controlling the niosome size.
使用不同摩尔分数的司盘-85和胆固醇制备了直径为8至15微米、含有利福平的非离子型表面活性剂囊泡（脂质体）。研究并优化了可能影响脂质体物理特性以及药物从脂质体中体外释放的工艺变量。对所制备脂质体的体内分布研究发现，通过控制脂质体大小，65%的药物可定位于肺部。
