Narla R S, Rao M N
Department of Pharmaceutical Chemistry, College of Pharmaceutical Sciences, Manipal, India.
J Pharm Pharmacol. 1995 Aug;47(8):623-5. doi: 10.1111/j.2042-7158.1995.tb05847.x.
The antioxidant properties of 3-phenylsydnone were studied in various models in-vitro. 3-Phenylsydnone scavenged the stable free radical, 1,1-diphenyl-2-picrylhydrazyl, and inhibited the degradation of deoxyribose mediated by hydroxyl radicals, although, to a lesser extent than trolox, a water soluble analogue of vitamin E. Many antioxidants possess pro-oxidant properties due to their ability to reduce ferric ions; however, 3-phenylsydnone was free from pro-oxidant properties, and also inhibited the lipid peroxidation induced by iron, in rat brain homogenates.
在多种体外模型中研究了3-苯基斯德酮的抗氧化特性。3-苯基斯德酮能清除稳定自由基1,1-二苯基-2-苦基肼，并抑制羟自由基介导的脱氧核糖降解，不过其抑制程度小于维生素E的水溶性类似物生育酚。许多抗氧化剂由于具有还原铁离子的能力而具有促氧化特性；然而，3-苯基斯德酮没有促氧化特性，并且还能抑制大鼠脑匀浆中铁诱导的脂质过氧化。
