Scavenging of free-radicals and inhibition of lipid peroxidation by 3-phenylsydnone.

The antioxidant properties of 3-phenylsydnone were studied in various models in-vitro. 3-Phenylsydnone scavenged the stable free radical, 1,1-diphenyl-2-picrylhydrazyl, and inhibited the degradation of deoxyribose mediated by hydroxyl radicals, although, to a lesser extent than trolox, a water soluble analogue of vitamin E. Many antioxidants possess pro-oxidant properties due to their ability to reduce ferric ions; however, 3-phenylsydnone was free from pro-oxidant properties, and also inhibited the lipid peroxidation induced by iron, in rat brain homogenates.