Paterson S
Animal Medical Centre, Chorlton, Manchester.
J Small Anim Pract. 1995 Sep;36(9):389-94. doi: 10.1111/j.1748-5827.1995.tb02961.x.
It has been reported that 20 to 70 per cent of atopic cases in the dog can be controlled with antihistamines, though the effective antihistamine cannot be predetermined. Combination therapy with essential fatty acids (EFAs) and antihistamines has been shown to be useful in dogs. All of the work published to date has been performed in open studies, without the use of placebo, and in dogs where the aim has been to control pruritus as a symptom rather than that caused specifically by atopy. The aim of this study was to assess the combined effects of four antihistamines; hydroxyzine, chlorpheniramine, cyproheptadine and clemastine; with both an EFA supplement and a placebo of olive oil, in 25 dogs to control pruritus in clinically proven cses of atopy.
据报道，犬类特应性病例中有20%至70%可以用抗组胺药控制，不过有效的抗组胺药无法预先确定。已证明，在犬类中，必需脂肪酸（EFA）与抗组胺药联合治疗是有用的。迄今为止发表的所有研究都是在开放研究中进行的，未使用安慰剂，且针对的犬类旨在控制瘙痒症状而非特应性具体引发的症状。本研究的目的是评估四种抗组胺药——羟嗪、氯苯那敏、赛庚啶和氯马斯汀——与EFA补充剂和橄榄油安慰剂联合使用对25只犬的综合效果，以控制经临床证实的特应性病例中的瘙痒。
