Brandenburg J H, Unger J M, Koschkee D
Department of Surgery, University of Wisconsin, Madison, USA.
Laryngoscope. 1996 Feb;106(2 Pt 1):174-80. doi: 10.1097/00005537-199602000-00013.
Since 1987, the senior author has injected autogenous fat into paralyzed or atrophic vocal cords as an alternative to alloplastic substances for vocal cord augmentation and medialization. To determine the fate of the injected autogenous fat, the injected vocal cords of 10 patients were evaluated by laryngeal magnetic resonance imaging (MRI) in the sagittal, coronal, and axial planes. Imaging studies were performed as early as 17 hours after surgery to as long as 31 months after fat injection. In 9 patients, identification of a fat signal within the previously injected vocal cords was observed (including the 31-month postoperative follow-up). In 1 patient, no fat signal was identified 13 months after surgery, but the vocal cord was noted to have a bulging, enlarged contour. The results of this imaging study provide further evidence that autogenous fat, which has not been damaged during harvesting or microinjection, can survive transplantation into the vocal cord. The bulk of the vocal cord is maintained by microlipocytes and fibrous connective tissue, both of which replace the damaged fat cells that are gradually being reabsorbed.
自1987年以来，资深作者已将自体脂肪注射到麻痹或萎缩的声带中，作为替代异体物质进行声带增厚和内移的方法。为了确定注射的自体脂肪的转归，对10例患者注射后的声带进行了喉磁共振成像（MRI）矢状面、冠状面和轴位扫描评估。成像研究最早在术后17小时进行，最晚在脂肪注射后31个月进行。9例患者在先前注射的声带内观察到脂肪信号（包括术后31个月的随访）。1例患者术后13个月未发现脂肪信号，但发现声带轮廓膨隆、增大。这项成像研究结果进一步证明，在采集或微量注射过程中未受损的自体脂肪能够在移植到声带后存活。声带的体积由微脂肪细胞和纤维结缔组织维持，二者替代了逐渐被吸收的受损脂肪细胞。
