Rolland A, Paul F, Stott K M, Olliff C J
SmithKline Beechams, Epsom, England.
Pharm Res. 1995 Oct;12(10):1435-8. doi: 10.1023/a:1016214900055.
This work was carried out to determine the surface tension of block copolymer micelles of 14C labelled ABA poly (oxyethylene-bi-isoprene-b-oxyethylene) which have a long circulating half life in animals.
The method used was that of phagocytosis. The percentage of micelles phagocytosed by human mononuclear cells was determined in solutions of different surface tension.
The values obtained were 72 mN/m which may be predicted for a particle with a long circulating half life in animals. The method also gave an estimate of the surface tension for the mononuclear cells.
This technique has the advantage of determining the surface tension of highly hydrated small particles including stable micelles in an environment similar to that in which they normally exist.
开展这项工作是为了测定具有长循环半衰期的14C标记的ABA型聚（氧乙烯-双异戊二烯-氧乙烯）嵌段共聚物胶束的表面张力。
采用的方法是吞噬作用法。在不同表面张力的溶液中测定人单核细胞吞噬的胶束百分比。
得到的值为72 mN/m，这对于在动物体内具有长循环半衰期的颗粒来说是可以预测的。该方法还给出了单核细胞表面张力的估计值。
这项技术的优点是能够在与高度水合的小颗粒（包括稳定胶束）通常所处环境相似的条件下测定其表面张力。
