Zahn V, Bittner S, Zach H P
Geburtshilfe Frauenheilkd. 1977 Mar;37(3):207-15.
During the first stage of labour 48 parturients were treated with the tocolytic agent TH 1165 a (Fenoterol-hydrobromide) because of danger to the foetus. The product was slowly injected i.v. in doses of 50 mcg (35 pat.) and 25 mcg (9 pat.) and on 4 patients in doses of 35 mcg. We investigated the effects of this therapy on labour, on the mother's and the child's circulation and on the foetal acid-base balance and foetal gas partial pressure. Whilst the different TH 1165a doses were not markedly different in their tocolytic effect, we discovered that side-effects occurred considerably more often and more intensively when higher doses of TH 116A WERE ADMINISTERED. We therefore recommend one i.v. injection of 25 mcg TH 1165a for clinical uterine relaxation in emergencies during labour. To guard against a vena cava compression syndrome, the injection should always be given with the patient in a lateral position. In emergency uterine relaxation the cardiac tocography (supplemented if necessary by micro blood gas analysis) should be monitored. In order tnce-only syringe containing 25 mcg TH1165a.
在第一产程中，48名产妇因胎儿面临危险而接受了宫缩抑制剂TH 1165a（氢溴酸非诺特罗）治疗。该药物通过静脉缓慢注射，剂量为50微克（35名患者）、25微克（9名患者），4名患者的剂量为35微克。我们研究了这种治疗方法对产程、母婴循环以及胎儿酸碱平衡和胎儿气体分压的影响。虽然不同剂量的TH 1165a在宫缩抑制效果上没有显著差异，但我们发现，给予较高剂量的TH 116A时，副作用出现的频率更高、程度更严重。因此，我们建议在分娩紧急情况下，为使子宫松弛，静脉注射25微克TH 1165a。为防止腔静脉压迫综合征，注射时患者应始终处于侧卧位。在紧急子宫松弛的情况下，应监测心脏产程图（必要时辅以微量血气分析）。准备一支单次使用的注射器，内含25微克TH1165a。
