Herink J
Military Medical Academy, Hradec Králové.
Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove. 1995;38(2):85-8.
Convulsive activity of N-(3,5-dimethoxy-4-propoxy-phenyl-ethyl)-aziridine (FAZ-4), a newly synthetized aziridine compound was studied in rats. There is a lack of tonic component of major paroxysm in comparison with the classical convulsive agent pentylenetetrazol. This effect of FAZ-4 is probably due to the forebrain mechanism without the midbrain involvement. Both anticonvulsants tested suppressed seizures in a different manner, however triazolam exerted stronger anticonvulsive activity than the same dose of diazepam did.
研究了一种新合成的氮丙啶化合物N-(3,5-二甲氧基-4-丙氧基-苯乙基)-氮丙啶（FAZ-4）在大鼠体内的惊厥活性。与经典惊厥剂戊四氮相比，主要发作的强直成分缺乏。FAZ-4的这种作用可能归因于前脑机制，而不涉及中脑。所测试的两种抗惊厥药以不同方式抑制癫痫发作，然而三唑仑比相同剂量的地西泮表现出更强的抗惊厥活性。
