Roliński Z, Tusińska E, Klimont E
Department of Pharmacology, University of Agriculture, Lublin, Poland.
Pol J Pharmacol Pharm. 1990 Mar-Apr;42(2):105-11.
The possibility to elicit convulsions in rabbits after flunarizine, iv was investigated. A flunarizine solution, 3.3 mg/ml, was given iv at a rate of 1.5 ml/min in three fractional doses every 30 min. Action of anti-epileptic drugs in seizures induced by flunarizine was additionally examined. Convulsive seizures occurred 2-10 min after the last successive dose of flunarizine as alternating clonic and tonic seizures. A treatment with anti-epileptic drugs showed that both phenobarbital at doses 6, 7 and 7.5 mg/kg iv and pentobarbital at doses of 15, 20 and 25 mg/kg, iv did not entirely suppress convulsive seizures, although convulsive episodes were rare. Diazepam at doses of 1-1.5 mg/kg, iv suppressed convulsive seizures.
研究了氟桂利嗪静脉注射后诱发家兔惊厥的可能性。以1.5 ml/min的速度静脉注射3.3 mg/ml的氟桂利嗪溶液，分三次给药，每次间隔30分钟。此外，还研究了抗癫痫药物对氟桂利嗪诱发惊厥的作用。在最后一次连续注射氟桂利嗪后2 - 10分钟出现惊厥性癫痫发作，表现为阵挛性和强直性发作交替。抗癫痫药物治疗表明，静脉注射剂量为6、7和7.5 mg/kg的苯巴比妥以及静脉注射剂量为15、20和25 mg/kg的戊巴比妥均不能完全抑制惊厥性癫痫发作，尽管惊厥发作很少见。静脉注射剂量为1 - 1.5 mg/kg的地西泮可抑制惊厥性癫痫发作。
