Kubová Z, Kuba M
Department of Physiology, Medical Faculty Charles University, Hradec Králové.
Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove. 1995;38(2):89-93.
In addition to standard pattern-reversal VEPs, the motion-onset VEPs were examined in 50 patients with acute unilateral retrobulbar neuritis (RN) and in 187 patients with possible or definite multiple sclerosis (MS). In MS patients (without sign or history of RN), the results of both types of VEPs correlated only partially. 26.2% of them displayed changes only in the motion-onset VEPs having the pattern-reversal VEPs completely normal. That is why we suppose that the magnocellular system (tested by motion-onset VEPs) can be affected by demyelination separately. In 28 patients with "pure" RN (without any other sign indicating demyelination disease) the always abnormal pattern-reversal VEPs were accompanied by delayed motion-onset VEPs in only 28.6% of patients. In contrast, much higher rate--68.2%--of delayed motion-onset VEPs was found in the 22 RN patients simultaneously suspected of MS These results indicate that RN affects predominantly the parvocellular visual system (tested by reversal VEPs). Distinct latency changes of the motion-onset VEP's in RN patients seem to signal a linkage between RN and demyelination.
除了标准的图形翻转视觉诱发电位（VEP）外，还对50例急性单侧球后视神经炎（RN）患者和187例可能患有或确诊为多发性硬化症（MS）的患者进行了运动起始视觉诱发电位检查。在MS患者（无RN体征或病史）中，两种类型的VEP结果仅部分相关。其中26.2%的患者仅运动起始视觉诱发电位出现变化，而图形翻转视觉诱发电位完全正常。这就是为什么我们认为大细胞系统（通过运动起始视觉诱发电位检测）可能单独受到脱髓鞘的影响。在28例“单纯”RN患者（无任何其他提示脱髓鞘疾病的体征）中，始终异常的图形翻转视觉诱发电位仅在28.6%的患者中伴有运动起始视觉诱发电位延迟。相比之下，在22例同时怀疑患有MS的RN患者中，运动起始视觉诱发电位延迟的发生率更高，为68.2%。这些结果表明，RN主要影响小细胞视觉系统（通过翻转视觉诱发电位检测）。RN患者运动起始视觉诱发电位明显的潜伏期变化似乎表明RN与脱髓鞘之间存在联系。
