Inch W R, McCredie J A, Haynes M J, Sutherland R M
Growth. 1977 Mar;41(1):15-23.
Metronidazole (0.6 mg/gm) was injected intraperitoneally at 12 hour intervals for 10 days into C3H/HeJ mice with established C3HBA mammary adenocarcinomas. Tumor growth, total white cell count and body weight were decreased by 3 days. Heart rate and rectal temperature were depressed most following the initial injections but were less depressed by 10 days. Hemoglobin and hematocrit were not changed. Plasma assays of total protein, uric acid, bilirubin, alkaline phosphatase and calcium were not affected. It was not possible to separate the tumors treated with metronidazole from control tumors, based on cellular differences. Blood vessels in most of the tumors in the drug treated animals were larger and appeared engorged with blood.
以12小时间隔，向患有已形成的C3HBA乳腺腺癌的C3H/HeJ小鼠腹腔内注射甲硝唑（0.6毫克/克），持续10天。3天时肿瘤生长、白细胞总数和体重下降。最初注射后心率和直肠温度下降最为明显，但到10天时下降程度减轻。血红蛋白和血细胞比容未发生变化。血浆总蛋白、尿酸、胆红素、碱性磷酸酶和钙的检测未受影响。基于细胞差异，无法将用甲硝唑治疗的肿瘤与对照肿瘤区分开来。用药治疗动物的大多数肿瘤中的血管更大，且看起来充满血液。
