Pelletier X, Belbraouet S, Mirabel D, Mordret F, Perrin J L, Pages X, Debry G
Centre de Nutrition Humaine, Nancy, France.
Ann Nutr Metab. 1995;39(5):291-5. doi: 10.1159/000177875.
Twelve normolipidic healthy human subjects were fed a diet with or without additional soybean phytosterols for 4 weeks in a crossover design. The order of the treatments was randomized. Phytosterols were added to the diet blended in butter. The dietary ratio cholesterol:phytosterols was 0.7 during the control period (436 mg cholesterol/day and 29 mg phytosterols/day) and 1.88 during the phytosterols period (410 mg cholesterol/day and 740 mg phytosterols/day). Blood cholesterol was 10% lower after subjects consumed the phytosterol-enriched diet than when they consumed the control diet (p < 0.001), which was due to a 15% LDL cholesterol decrease (p < 0.001). The HDL cholesterol:LDL cholesterol ratio was markedly enhanced (+25%) (p < 0.01). These findings suggest that a significant lowering of plasma total and LDL cholesterol can be effected by a modest dietary intake of soybean phytosterols.
12名血脂正常的健康受试者采用交叉设计，接受了为期4周的含或不含额外大豆植物甾醇的饮食。治疗顺序是随机的。植物甾醇被添加到与黄油混合的饮食中。在对照期，饮食中胆固醇与植物甾醇的比例为0.7（每日436毫克胆固醇和29毫克植物甾醇），在植物甾醇期为1.88（每日410毫克胆固醇和740毫克植物甾醇）。受试者食用富含植物甾醇的饮食后，血液胆固醇水平比食用对照饮食时低10%（p<0.001），这是由于低密度脂蛋白胆固醇降低了15%（p<0.001）。高密度脂蛋白胆固醇与低密度脂蛋白胆固醇的比例显著提高（+25%）（p<0.01）。这些发现表明，适度饮食摄入大豆植物甾醇可显著降低血浆总胆固醇和低密度脂蛋白胆固醇水平。
