Fujiwaki R, Hata T, Hata K, Kitao M, Furuya H, Katoh Y
Department of Obstetrics and Gynecology, Simane Medical University, Izumo, Japan.
Gynecol Obstet Invest. 1995;40(4):276-7. doi: 10.1159/000292355.
Drug-induced immune system mediated agranulocytosis is a rare but potentially life-threatening condition. There have been only a few reports on the drug-induced agranulocytosis during pregnancy. We present a case of agranulocytosis after prolonged intravenous infusion of ritodrine hydrochloride and additional administration of indomethacin suppositories, effectively treated using recombinant human granulocyte colony stimulating factor without any infection in a mother with twin-to-twin transfusion syndrome. Recombinant human granulocyte colony stimulating factor may have a potential use for drug-induced agranulocytosis during pregnancy.
药物诱导的免疫系统介导的粒细胞缺乏症是一种罕见但可能危及生命的病症。关于孕期药物诱导的粒细胞缺乏症仅有少数报道。我们报告一例双胎输血综合征母亲在长时间静脉输注盐酸利托君并额外使用吲哚美辛栓剂后发生粒细胞缺乏症的病例，该病例使用重组人粒细胞集落刺激因子有效治疗，且未发生任何感染。重组人粒细胞集落刺激因子可能对孕期药物诱导的粒细胞缺乏症有潜在用途。
