Magner J A, Snyder D K
Department of Medicine, East Carolina University School of Medicine, Greenville, North Carolina 27858.
Thyroid. 1994 Fall;4(3):295-6. doi: 10.1089/thy.1994.4.295.
A 35-year-old female hematology technician with Graves' disease developed agranulocytosis a few days after starting therapy with Tapazole (methimazole). Because of a recent report of use of recombinant human granulocyte colony-stimulating factor (G-CSF) in patients with propylthiouracil-induced agranulocytosis, 5 micrograms/kg/day G-CSF was administered and her granulocyte count returned to normal after three doses, on the sixth day after the last dose of methimazole. We conclude that in patients with drug-induced agranulocytosis, the use of G-CSF, in addition to discontinuation of the offending drug, hastens recovery and reduces morbidity.
一名35岁患有格雷夫斯病的女性血液学技术员在开始服用他巴唑（甲巯咪唑）治疗几天后发生了粒细胞缺乏症。由于最近有关于重组人粒细胞集落刺激因子（G-CSF）用于丙硫氧嘧啶诱导的粒细胞缺乏症患者的报道，给予患者5微克/千克/天的G-CSF，在最后一剂甲巯咪唑后的第六天，三剂后她的粒细胞计数恢复正常。我们得出结论，在药物性粒细胞缺乏症患者中，除停用致病药物外，使用G-CSF可加速恢复并降低发病率。
