Desai A, Ravi V, Chandramuki A, Gourie-Devi M
Department of Neurovirology, National Institute of Mental Health and Neurosciences, Bangalore, India.
Intervirology. 1994;37(6):352-5. doi: 10.1159/000150400.
This paper reports the direct evidence for the presence of Japanese encephalitis virus (JEV)-specific immune complexes in the CSF of 31/185 confirmed patients for the first time. A monoclonal antibody-based capture ELISA was used for the detection of immune complexes. Amongst the 31 cases positive for immune complexes, 14 were positive for JEV IgM antibodies and/or neutralizing antibodies in the CSF, 6 were positive for viral antigen in the CSF and 11 for both antibody and antigen. Correlation of findings to final outcome revealed that the presence of immune complexes in CSF was significantly associated with death (p = 0.01).
本文首次报告了在185例确诊患者中的31例脑脊液中存在日本脑炎病毒（JEV）特异性免疫复合物的直接证据。采用基于单克隆抗体的捕获ELISA法检测免疫复合物。在31例免疫复合物阳性病例中，14例脑脊液中JEV IgM抗体和/或中和抗体呈阳性，6例脑脊液中病毒抗原呈阳性，11例抗体和抗原均呈阳性。研究结果与最终结局的相关性显示，脑脊液中免疫复合物的存在与死亡显著相关（p = 0.01）。
