Wernig A, Irintchev A
Department of Physiology, Neurophysiology, University of Bonn, Germany.
J Neurol Sci. 1995 Jun;130(2):190-6. doi: 10.1016/0022-510x(95)00034-y.
Transplantation of normal myoblasts has been considered a potential therapy for muscle dystrophies. While survival of implanted cells has been described in animal experiments and in human trials, functional effects remained unclear. Here we report on survival of progenors of implanted C2nlsBAG cells in regenerating muscles but irreversible net loss in muscle tissue and contractile force. This is caused by immune rejection of implanted myoblasts despite MHC-compatibility and "bystander" damage of host muscle tissue.
正常成肌细胞移植已被视为治疗肌肉萎缩症的一种潜在疗法。虽然在动物实验和人体试验中均已描述了植入细胞的存活情况，但其功能效果仍不明确。在此，我们报告植入的C2nlsBAG细胞的后代在再生肌肉中的存活情况，但肌肉组织和收缩力出现了不可逆的净损失。这是由植入的成肌细胞的免疫排斥反应导致的，尽管主要组织相容性复合体（MHC）具有相容性，且宿主肌肉组织也受到了“旁观者”损伤。
