Successful treatment of interstitial lung disease in systemic lupus erythematosus with methotrexate.

Corticosteroids are the accepted medical therapy of interstitial lung disease associated with systemic lupus erythematosus (SLE). We describe a case with a marked improvement in clinical status, pulmonary function testing and gallium lung scanning after treatment of interstitial pulmonary disease associated with SLE with weekly oral methotrexate alone.