Sanyal P K
Animal Disease Research Laboratory, National Dairy Development Board, Gujarat, India.
J Vet Pharmacol Ther. 1995 Oct;18(5):370-4. doi: 10.1111/j.1365-2885.1995.tb00606.x.
Concentrations of triclabendazole sulfoxide and its sulfone metabolite in plasma were measured in buffalo and cross-bred cattle after single intraruminal administration of triclabendazole at two different doses. Plasma concentrations of both metabolites were significantly lower in buffalo than cattle at both doses, which resulted in a smaller area under the concentration-time curve, a lower concentration maximum and a lower relative bioavailability. Thus, the recommended doses of 12 mg/kg body weight for the treatment of bubaline fascioliasis may not be valid for buffalo because of the substantially lower uptake of the drug in this species.
